PLGA™

Sustained release pharmaceutical base material

Applications detail

Controlled-release pharmaceuticals

Applications

Raw materials for pharmaceuticals etc.
Other (chemical products)

Overview

Mitsui PLGA is a high quality excipient for controlled-extended release of drugs, for industrial usage.

PLGA
  • Least Residual Solvent
  • Well-Controlled Molecular Weight
  • Drug Master File Registered with
    - FDA（USA）
    - Health Canada(Canada)
  • cManufactured under cGMP

Properties

PLGA Properties
  • Degraded into glycolic acid and lactic acid by hydrolysis
  • Specific rate of degradation depending on its copolymer ratio and molecular weight
Physical Properties
CAS No.26780-50-7
Chemical Formula( C4H4O4 )x ( C6H8O4 )y
Colorwhite to light tan
Odorodorless
Tm (Melting Point) / ℃－
Tg (Glass Transition) / ℃45-55
SolventCH2Cl2
CHCl3
DMF
DMSO
THF
Properties of the Standard Grade
PolymerCo-polymer Ratio*Inherent Viscosity**Molecular WeightResidual MonomerSn ContentHeavy MetalsSulphated Ash
(mol%)(dL/g)(kDa)(%)(ppm)(ppm)(%)
GLDLTD  GLDLTD   
PLGA
5-50		45-5545-550.45-0.60(50-55)< 2.0< 2.0< 50< 10< 0.1
PLGA
75-75		20-3070-800.72 – 0.80(78 – 85)< 2.0< 2.0< 50< 10< 0.1
PLGA
75-65		0.60-0.70(62-76)
PLGA
75-50		0.45-0.55(50-60)
  • Mitsui PLGA GRADE NAMING/li>
  • PLGA Lactide-Viscosity
  • EX : PLGA 5-50
  • Lactide 50 : 50, Viscosity 0.50 dL/g

*Inherent Viscosity : 0.5 g/dl (Chloroform), @25 C
**Molecular Weight (by GPC) : (Standard polymer-Solvent) PMMA-HFIP for PGA, PS-THF for PLGA

We also welcome your requests on customize products, for more than a demand of 5kg/year.

Hydrolysis of PLGA in vitro (Residual Weight)
Hydrolysis of PLGA in vitro (Molecular Weight)

Contact Us

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MITSUI CHEMICALS INDIA, PVT. LTD.
TEL +91-99588 10725
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